video1.0<iframe src="https://www.loom.com/embed/86996ec2f45e4d0183c3bc0ff4a2f378" frameborder="0" width="1728" height="1296" webkitallowfullscreen mozallowfullscreen allowfullscreen></iframe>12961728Loomhttps://www.loom.com12961728https://cdn.loom.com/sessions/thumbnails/86996ec2f45e4d0183c3bc0ff4a2f378-68884b4a5b8237fd.gif335.054This Loom explains the Configuration settings in the Setup Utilities, focusing on Port Assignments and key monitoring and priming options. It covers selecting port assignment presets like Standard and Standard with Mix, noting instruments ship with a mixing chamber as an option to free up a manifold port when not used. It recommends keeping tridle monitoring enabled and setting the empty tridle monitor time based on scale: 10 to 20 seconds for standard non-VLS models, up to 20 for H16 or H32, and close to 40 for VLS. It also discusses dual column injection tradeoffs, mid-synthesis priming to fill manifold dead space before injection, and reverse purge columns behavior and default settings.