video1.0<iframe src="https://www.loom.com/embed/a8baa478d04a44f4a740c38d5aa03e30" frameborder="0" width="1298" height="973" webkitallowfullscreen mozallowfullscreen allowfullscreen></iframe>9731298Loomhttps://www.loom.com9731298https://cdn.loom.com/sessions/thumbnails/a8baa478d04a44f4a740c38d5aa03e30-da32ab3ec96302d3.gif86.319This Loom discusses a cancer screening research question audit and why the protocol missed its endpoint. It explains that the problem was the wrong research question for a low prevalence population, where a composite cancer endpoint created many false alarms among the general NHS screening population. The hypothesis that sounded reasonable was reviewed and found to be flawed, with a “phlob of a protocol lock” noted. The logic is that positive tests shift from mostly false alarms in the general population to flipping in a higher risk or richer group, which the trial missed due to question design rather than technology.