video1.0<iframe src="https://www.loom.com/embed/b1abd98c711042a190507c872c6db8d3" frameborder="0" width="1728" height="1296" webkitallowfullscreen mozallowfullscreen allowfullscreen></iframe>12961728Loomhttps://www.loom.com12961728https://cdn.loom.com/sessions/thumbnails/b1abd98c711042a190507c872c6db8d3-34f66cb58f94a283.gif597.141In this video, I discuss modafinil and armodafinil, focusing on their mechanisms of action as dopamine reuptake inhibitors that enhance wakefulness through the orexin system. I highlight their pharmacokinetics, with modafinil lasting about 15 hours and armodafinil providing a smoother blood level profile. I often use armodafinil in my practice for patients with bipolar disorder and ADHD, as it has shown success without the risks associated with traditional stimulants. I also touch on its off-label use for treatment-resistant depression, particularly for fatigue. Please consider these insights when evaluating treatment options for patients experiencing excessive daytime sleepiness or cognitive impairments.